INDEPENDENT REVIEW OF RESEARCH PROPOSALS FROM ETHICAL POINT OF VIEW IN PAKISTAN

Authors

  • Mohammad Salim
  • Saima Hamid

Abstract

Background: Ethics is a part of subject philosophy and gained importance in research after the Nuremberg Code that led to Helsinki's Declaration on research ethics. In most developed countries stringent measures are taken to implement ethics in research. Awareness is on the rise in developing countries too. Methods: This cross-sectional part of mixed methods design of study is part of a PhD thesis. Data was collected from medical institutions including medical colleges, medical universities, dental colleges, and teaching hospitals of Pakistan. Questionnaires were developed, and final version was adopted after pretesting. Questionnaires were sent via registered post. Results: A total of 78 institutions responded. Out of 78, 48 (61.5%) were in public sector and 30(38.5%) in private sector. Seventy-four (94%) had institutional review boards.  The numbers of members ranged from 1 to 15 with 40(54%) having number of members from 3 to 7. Out of 74 with IRBs, 17(23%) had members from community, 11(15%) had religious scholars and 8(11%) had members from legal background. Sixty-four (86.5%) responded that they had time frames for research proposal processing that ranged from one to 26 weeks (6.2±5.6) Conclusion:  It is concluded that most of the medical institutions where research is conducted and approved through deficient research ethical boards in terms of their constitution. Research ethics is not a priority area for most of the institutions.  Representation of society at large is missing. National action is required at government level.

Keywords: Institutional Review Boards; Research Ethics; Ethics Committees; Constitution of IRBs

References

Moll J, Oliveira-Souza R, Garrido GJ, Bramati IE, Caparelli-Daquer EM, Paiva ML, et al. The self as a moral agent: linking the neural bases of social agency and moral sensitivity. Soc Neurosci 2007;2(3-4):336-52.

Soskolne CL, Last JM. Ethics and public health policy. In: Wallace RB, editor. Wallace/Maxcy -Rosenau-Last Public health and preventive medicine. 15th ed. New York: McGraw Hill Medical, 2008; p.248-57.

Markman JR, Markman M. Running an ethical trial 60 years after the Nuremberg Code. Lancet Oncol 2007;8(12):1139-46.

Taylor RM. Ethical principles and concepts in medicine. Handb Clin Neurol 2012;118:1-9.

World Medical Association. World Medical Association Declaration of Helsinki. Ethical principles for medical research involving human subjects. Bull World Health Organ 2001;79(4):373-4.

World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 2013;310(20):2191-4.

Christakis NA. Should IRBs monitor research more strictly? IRB 1988;10(2):8-10.

Heath EJ. The IRB's monitoring function: four concepts of monitoring. IRB 1979;1(5):1-12.

Brown P, Morello-Frosch R, Brody JG, Altman RG, Rudel RA, Senier L, et al. Institutional review board challenges related to community-based participatory research on human exposure to environmental toxins: A case study. Environ Health 2010;9(1):39.

Emanuel EJ, Wendler D, Grady C. What makes clinical research ethical? JAMA 2000;283(20):2701-11.

Bauchner H, Sharfstein J. Failure to report ethical approval in child health research: review of published papers. BMJ 2001;323(7308):318-9.

Hyder AA, Nadeem S. Health ethics in Pakistan: a literature review of its present state. J Health Popul Nutr 2001;19(1):6-11.

Humayun A, Fatima N, Naqqash S, Hussain S, Rasheed A, Imtiaz H, et al. Patients' perception and actual practice of informed consent, privacy and confidentiality in general medical outpatient departments of two tertiary care hospitals of Lahore. BMC Med Ethics 2008;9(1):14.

Abrar S, Ronis KA, Khan S, Siraj S, Safdar W, Khalid Y, et al. Status of ethical review boards at all medical colleges of Khyber Pakhtunkhwa. J Ayub Med Coll Abbottabad 2015;27(2):411-4.

WHO. Research ethics. Geneva: World Health Organization 2014. [Internet]. [cited 2017 Jun] Available from: http://www.who.int/rpc/research_ethics/en

Nishtar S, Mehboob AB. Pakistan prepares to abolish Ministry of Health. Lancet 2011;378(9792):648-9.

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Published

2018-12-01

How to Cite

Salim, M., & Hamid, S. (2018). INDEPENDENT REVIEW OF RESEARCH PROPOSALS FROM ETHICAL POINT OF VIEW IN PAKISTAN. Journal of Ayub Medical College Abbottabad, 30(4), 588–591. Retrieved from https://www.demo.ayubmed.edu.pk/jamc/index.php/jamc/article/view/6026

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