RARE CASE REPORT: SPINDLE CELL CARCINOMA WITH UNUSUAL METASTASIS TO THE BREAST

Authors

  • Shumaila Seemi Malik Al Noor Diagnostic Center Lahore-Pakistan
  • Syed Muhammad Hadi Ali Shah Al Noor Diagnostic Center Lahore-Pakistan https://orcid.org/0009-0001-6925-8662
  • Maheen Nasir CMH LMC & IOD
  • Safdar Ali Malik Al Noor Diagnostic Center Lahore-Pakistan
  • Fahad Malik CMH Lahore Medical and Dental College,Lahore-Pakistan

DOI:

https://doi.org/10.55519/JAMC-S4-12535

Keywords:

breast, breast cancer, metastasis

Abstract

Primary breast cancer is the most common malignancy in women, with metastatic involvement of the breast being quite an anomaly. Metastasis in the breast refers to cancer cells from elsewhere in the body, which infiltrate into the breast tissue. Spindle cell carcinoma is an aggressive subtype of sarcoma and is so named because of the characteristic spindle-shaped cells. Spindle cell carcinoma is a very rare type of cancer and accounts for only a few cancer cases as compared to adenocarcinoma or squamous cell carcinoma. However, due to its aggressive nature, it can rapidly spread to adjacent tissues and may even metastasize to distant organs including the lungs, gastrointestinal tract and as highlighted here; the breast. Case: We present the case of an 81-year-old female with the complaint of a painless nontender lump in the right breast for the last month. After proper investigations, a diagnosis of spindle cell carcinoma was confirmed. On CT chest, abdomen and pelvis for a proper workup for metastasis, an incidental note was made of a mass in the anterior right thigh. On further inquiry from the patient, it was found that the mass had been present for the last year but appropriate investigations had not been done. Fine needle aspiration (FNAC) and biopsy confirmed a diagnosis of spindle cell carcinoma of the right thigh, which had been missed in initial investigations. Conclusion: This case report highlights that in every patient who presents with a breast mass, proper clinical evaluation and diagnostic investigations are necessary to rule out the possibility of metastasis.

References

1. Tsang JYS, Tse GM. Molecular Classification of Breast Cancer. 2020;27(1):27–35.

2. Murtaza G, Shuib L, Abdul Wahab AW, Mujtaba G, Mujtaba G, Nweke HF, et al. Deep learning-based breast cancer classification through medical imaging modalities: state of the art and research challenges. Artif Intell Rev 2020;53(3):1655–720.

3. Li Z, Wei H, Li S, Wu P, Mao X. The Role of Progesterone Receptors in Breast Cancer. Drug Dis Devel Ther 2022;16:305–14.

4. Smolarz B, Zadrożna Nowak A, Romanowicz H. Breast Cancer—Epidemiology, Classification, Pathogenesis and Treatment (Review of Literature). Cancers (Basel) 2022;14(10):2569.

5. Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, et al. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature 2012;486(7403):346–52.

6. Metzger-Filho O, Tutt A, De Azambuja E, Saini KS, Viale G, Loi S, et al. Dissecting the heterogeneity of triple-negative breast cancer. J Clin Oncol 2012;30(15):1879–87.

7. Mayer IA, Abramson VG, Lehmann BD, Pietenpol JA. New strategies for triple-negative breast cancer-deciphering the heterogeneity. Clin Cancer Res 2014;20(4):782–90.

8. Yin L, Duan JJ, Bian XW, Yu SC. Triple-negative breast cancer molecular subtyping and treatment progress. Breast Cancer Res 2020;22(1):61.

9. Lu B, Natarajan E, Balaji Raghavendran HR, Markandan UD. Molecular Classification, Treatment, and Genetic Biomarkers in Triple-Negative Breast Cancer: A Review. Technol Cancer Res Treat 2023;2023:15330338221145246.

10. Espinoza JLH, Ramírez FNM, Miller HG, Santos JLH, Guelfguat M. A Spectrum of Metastases to the Breast: Radiologic-Pathologic Correlation. J Breast Imaging 2023;(2):209–29.

11. Nozoe E, Nozoe T, Tanaka J, Ohga T, Fujita A, Sueishi K. Spindle cell carcinoma of the breast – a case report. J Med Invest 2020;67(3.4):365–7.

12. Ishizuka Y, Horimoto Y, Yanagisawa N, Arakawa A, Nakai K, Saito M. Clinicopathological Examination of Metaplastic Spindle Cell Carcinoma of the Breast: Case Series. Breast Cancer (Auckl) 2021;15:11782234211039433.

13. Alexander JS, Hashmi H, Reynolds SB. Debilitating Metastatic Spindle Cell Carcinoma of the Breast. Cureus 2019;11(1):e3864.

14. Gersell DJ, Katzenstein ALA. Spindle cell carcinoma of the breast. A clinocopathologic and ultrastructural study. Hum Pathol 1981;12(6):550–61.

15. El All HSA. Breast spindle cell tumours: About eight cases. Diagn Pathol 2006;1(1):13.

Downloads

Published

2024-12-16

How to Cite

1.
Malik SS, Shah SMHA, Nasir M, Malik SA, Malik F. RARE CASE REPORT: SPINDLE CELL CARCINOMA WITH UNUSUAL METASTASIS TO THE BREAST. J Ayub Med Coll Abbottabad [Internet]. 2024 Dec. 16 [cited 2025 Dec. 6];36(4 (Suppl 1):1014-7. Available from: https://www.demo.ayubmed.edu.pk/index.php/jamc/article/view/12535